Bliss opens with our protagonist Greg (Owen Wilson) drawing familiar sights from his active imagination, with varied locations and a mysterious woman making up the portfolio strewn across his desk. But in a matter of minutes, he loses his job, accidentally murders his boss, and finds out that Isabel (Salma Hayek), the woman of his literal dreams, actually exists outside of his sketches. It’s in the aftermath of all this that Isabel tells Greg that his world is not as real as he thinks, sending Bliss’ leads down a rabbit hole of crystalized drugs, a complex simulated world, and a very wary Bill Nye.

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